Genus Cosavirus

Genus Cosavirus presently comprises 5 species, 1 tentative species awaits classification:

Cosavirus A, 26 types.
Cosavirus B, 2 types.
Cosavirus C (CosV-C), 1 type, awaits classification.
Cosavirus D, 6 types.
Cosavirus E, 2 types.
Cosavirus F, 1 type.

Subtyping of human cosaviruses is only preliminary as it is based on partial VP3-VP1 sequences only (Kapusinszky et al. 2012); several errors have been corrected. Subtpyping is complicated by two inter-species recombinants, one of which suggests the existence of a sixth cosavirus species.

Genome layout: VPg-5'UTRIRES-II[1A-1B-1C-1D-2Anpgp/2B-2Chel/3A- 3BVPg-3Cpro-3Dpol]3'UTR-poly(A)

This compilation comprises 73 GenBank entries!

Species

Type

Strain

Length

Acc. No.

Reference

Cosavirus A

HCoSV-A1

human cosavirus 1 (HCoSV-1)
strain 0553

7632 nt

FJ438902

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-20487.

NC_012800

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-20487.

HCoSV-A2

6344 (human/Pakistan)

7335 nt

FJ438903

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-20487.

HCoSV-A3

6572 (human/Pakistan)

6431 nt

FJ438904

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-20487.

HCoSV-A3

NG2 (human/Nigeria/2007)

910 nt
(VP3p-VP1p)

JN867791

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A3

NG349-2 (human/Nigeria/2007)

923 nt
(VP3p-VP1p)

JQ811828

Kapusinszky et al. 2012. Unpublished.

HCoSV-A3

NP7 (human/Nepal)

923 nt
(VP3p-VP1p)

JN867765

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A3

NG11 (human/Nigeria/2007)
(formerly HCoSV-A10)

912 nt
(VP3p-VP1p)

JN867772

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A3

NG26 (human/Nigeria/2007)
(formerly HCoSV-A10)

908 nt
(VP3p-VP1p)

JN867783

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A3

NP8-2 (human/Nepal)
(formerly HCoSV-A10)

911 nt
(VP3p-VP1p)

JQ811823

Kapusinszky et al. 2012. Unpublished.

HCoSV-A4

5006 (human/Pakistan)

2106 nt (VP4-VP2-VP3)

FJ438905

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-20487.

2263 nt (2C-3A-3B-3C-3D)

FJ438906

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-20487.

HCoSV-A5

NG6 (human/Nigeria/2007)

906 nt
(VP3p-VP1p)

JN867771

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A5

NG24 (human/Nigeria/2007)

904 nt
(VP3p-VP1p)

JN867781

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A5

NG25 (human/Nigeria/2007)

905 nt
(VP3p-VP1p)

JN867782

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A5

NG27 (human/Nigeria/2007)

905 nt
(VP3p-VP1p)

JN867784

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A5

NG28 (human/Nigeria/2007)

905 nt
(VP3p-VP1p)

JN867785

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A6

TN06-S231 (human/Tunisia/2006)

908 nt
(VP3p-VP1p)

JN867790

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A6

NP8-2 (human/Nepal)

908 nt
(VP3p-VP1p)

JQ811822

Kapusinszky et al. 2012. Unpublished.

HCoSV-A6

SH1 (human/China/2009)

7262 nt

GU968209

Dai et al. 2010. Human cosavirus infections in children in China. J. Clin. Virol. 48 (3), 228-229.

HCoSV-A6

CMH-N199-11 (human/Thailand/2011)

7802 nt

KJ396940

Khamrin & Maneekarn. 2014. Detection and genetic characterization of cosavirus in a pediatric patient with diarrhea. Arch. Virol. 159 (9), 2485-2489.

HCoSV-A7

NP11 (human/Nepal)

911 nt
(VP3p-VP1p)

JN867768

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A8

NG18 (human/Nigeria/2007)

905 nt
(VP3p-VP1p)

JN867776

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A8

NG349-1 (human/Nigeria/2007)

911 nt
(VP3p-VP1p)

JQ811827

Kapusinszky et al. 2012. Unpublished.

HCoSV-A9

NP5 (human/Nepal)

915 nt
(VP3p-VP1p)

JN867763

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A9

NP9 (human/Nepal)

914 nt
(VP3p-VP1p)

JN867766

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A9

TN06-E96 (human/Tunisia/2006)

913 nt
(VP3p-VP1p)

JN867788

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A9

NG366-2 (human/Nigeria/2007)

914 nt
(VP3p-VP1p)

JQ811833

Kapusinszky et al. 2012. Unpublished.

HCoSV-A11

NP1 (human/Nepal)

881 nt
(VP3p-VP1p)

JN867760

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A12

NG14 (human/Nigeria)

911 nt
(VP3p-VP1p)

JN867774

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A13

NP6 (human/Nepal)

905 nt
(VP3p-VP1p)

JN867764

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A14

NG12 (human/Nigeria/2007)

902 nt
(VP3p-VP1p)

JN867773

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A14

NG376 (human/Nigeria/2007)

928 nt
(VP3p-VP1p)

JQ811829

Kapusinszky et al. 2012. Unpublished.

HCoSV-A15

NG23 (human/Nigeria/2007)

886 nt
(VP3p-VP1p)

JN867780

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A16

NP10 (human/Nepal)

907 nt
(VP3p-VP1p)

JN867767

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A17

NG3 (human/Nigeria/2007)

905 nt
(VP3p-VP1p)

JN867769

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A17

NG5 (human/Nigeria/2007)

904 nt
(VP3p-VP1p)

JN867770

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A17

TN06-E10 (human/Tunisia/2006)

905 nt
(VP3p-VP1p)

JN867786

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A17

TN06-E34 (human/Tunisia/2006)

905 nt
(VP3p-VP1p)

JN867787

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A17

UP-IND-378 (human/India/2010)

886 nt
(VP3p-VP1p)

KC771253

Maan & Dhole. 2013. Unpublished.

HCoSV-A17

1143_67c (human/China/2011)

887 nt
(VP3p-VP1p)

KP213320

Yu & Duan. 2014. Unpublished.

HCoSV-A17

1113_87c (human/China/2011)

887 nt
(VP3p-VP1p)

KP213321

Yu & Duan. 2014. Unpublished.

HCoSV-A18

NG15 (human/Nigeria)

905 nt
(VP3p-VP1p)

JN867775

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A19

PK6187 (human/Pakistan/2006)

6635 nt

JN867759

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A20

NG263 (human/Nigeria/2007)

6635 nt

JN867756

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-A21

NG295-1 (human/Nigeria/2007)

911 nt
(VP3p-VP1p)

JQ811826

Kapusinszky et al. 2012. Unpublished.

HCoSV-A22

NG295-1 (human/Nigeria/2007)

914 nt
(VP3p-VP1p)

JQ811825

Kapusinszky et al. 2012. Unpublished.

HCoSV-A23

NG213-2 (human/Nigeria/2007)

905 nt
(VP3p-VP1p)

JQ811831

Kapusinszky et al. 2012. Unpublished.

HCoSV-A24

NP8-1 (human/Nepal)

905 nt
(VP3p-VP1p)

JQ811821

Kapusinszky et al. 2012. Unpublished.

HCoSV-A24

NG213-1 (human/Nigeria/2007)

905 nt
(VP3p-VP1p)

JQ811830

Kapusinszky et al. 2012. Unpublished.

HCoSV-A25

10928/2012/JPN (human/Japan)

7328 nt

AB920345

Okitsu et al. 2014. Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan. Infect. Genet. Evol. 28C, 125-129.

HCoSV-A26

UP-IND-151 (human/India/2010)

886 nt
(VP3p-VP1p)

KC771252

Maan & Dhole. 2013. Unpublished.

Cosavirus B

HCoSV-B1

2263 (human/Pakistan)

7205 nt

FJ438907

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-2048.

NC_012801

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-2048.

HCoSV-B2

1213_144 (human/China/2012)

880 nt
(VP3p-VP1p)

KP213322

Yu & Duan. 2014. Unpublished.

tentative Cosavirus C
(awaits classification)

HCoSV-C1

5152 (human/Pakistan)

2265 nt

FJ442995

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-2048.

Cosavirus D

HCoSV-D1

5004 (human/Pakistan)

7215 nt

FJ438908

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-2048.

NC_012802

Kapoor et al. 2008. A highly prevalent and genetically diversified Picornaviridae genus in South Asian children. Proc. Natl. Acad. Sci. U.S.A. 105 (51), 20482-2048.

HCoSV-D2

NP4 (human/Nepal)

905 nt
(VP3p-VP1p)

JN867762

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-D3

NG20 (human/Nigeria/2007)

913 nt
(VP3p-VP1p)

JN867778

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-D4

NP3 (human/Nepal)

910 nt
(VP3p-VP1p)

JN867761

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-D4

NG366-1 (human/Nigeria/2007)

908 nt
(VP3p-VP1p)

JQ811832

Kapusinszky et al. 2012. Unpublished.

HCoSV-D5

NG29 (human/Nigeria/2007)

901 nt
(VP3p-VP1p)

JN867777

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-D5

TN07-E126 (human/Tunisia/2007)

902 nt
(VP3p-VP1p)

JN867789

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

HCoSV-D6

Amsterdam/1994

7802 nt

KJ194505

Cotten et al. 2014. Full genome virus detection in fecal samples using sensitive nucleic acid preparation, deep sequencing, and a novel iterative sequence classification algorithm. PLoS ONE 9 (4), e93269.

NC_023984

Cotten et al. 2014. Full genome virus detection in fecal samples using sensitive nucleic acid preparation, deep sequencing, and a novel iterative sequence classification algorithm. PLoS ONE 9 (4), e93269.

Cosavirus E

HCoSV-E1

Australia/1981

6580 nt

FJ438908

Holtz et al. 2008. Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol. J. 5, 159.

NC_012798

Holtz et al. 2008. Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol. J. 5, 159.

HCoSV-E2

NG22 (human/Nigeria/2007)
(recombinant E2/D6)

901 nt
(VP3p-VP1p)

JN867779

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

Cosavirus F

HCoSV-F1

PK5006 (human/Pakistan/2007)

6656 nt

JN867758

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.

recombinant HCoSV-B2CP-GPol

recombinant HCoSV-B2CP-GPol strain JMY-2014 Cosa-CHN (human/China/2012)
[tentative new species: Cosavirus G?]

7213 nt

KM516909

Yu & Duan. 2014. Unpublished.

NC_025961

Yu & Duan. 2014. Unpublished.

recombinant HCoSV-E2CP-DPol

recombinant HCoSV-E2CP-DPol
strain NG385 (human/Nigeria/2007)

6752 nt

JN867757

Kapusinszky et al. 2012. Genetic diversity of the genus cosavirus in the family picornaviridae: a new species, recombination, and 26 new genotypes. PLoS ONE 7 (5), e36685.




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