Genus Hepatovirus

Genus Hepatovirus presently comprises 9 species:

Hepatovirus ahepa (formerly Hepatovirus A), 1 type (hepatitis A virus, HAV)
Hepatovirus bephopi (formerly Hepatovirus B), 1 type (phopivirus, PhV)
Hepatovirus cemanavi (formerly Hepatovirus C), 1 type (bat hepatovirus)
Hepatovirus devoli (formerly Hepatovirus D), 2 types (rodent hepatovirus)
Hepatovirus erebubrufu (formerly Hepatovirus E), 1 type (rodent hepatovirus)
Hepatovirus fejalco (formerly Hepatovirus F), 2 types (rodent hepatovirus)
Hepatovirus gafrisheta (formerly Hepatovirus G), 2 types
Hepatovirus hedgi (formerly Hepatovirus H), 3 types
Hepatovirus ishrewi (formerly Hepatovirus I), 1 type

Genome layout: VPg-5'UTRIRES-V[1A-1B-1C-1D/2A-2B-2Chel/3A- 3BVPg-3Cpro-3Dpol]3'UTR-poly(A)

This compilation is not comprehensive. There are more than 12.600 GenBank entries (as of 22 June 2026) !

Species

Type

Strain

Length

Acc. No.

Reference

Hepatovirus ahepa

(formerly
Hepatovirus A)

HAV

hepatitis A virus (HAV)
strain HM-175

7478 nt

M14707

Cohen et al. 1987. Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J. Virol. 61 (1):50-59.

NC_001489

Cohen et al. 1987. Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J. Virol. 61 (1):50-59.

HAV

simian hepatitis A virus
strain AGM-27

7400 nt

D00924

Tsarev et al. 1991. Simian hepatitis A virus (HAV) strain AGM-27: comparison of genome structure and growth in cell culture with other HAV strains. J. Gen. Virol. 72 (PT 7):1677-1683.

Hepatovirus bephopi

(formerly
Hepatovirus B)

PhV

phopivirus
strain New England/USA/2011

7476 nt

KR703607

Anthony et al. 2015. Discovery of a novel hepatovirus (phopivirus of seals) related to human hepatitis A virus. MBio 6 (4):e01180-15.

NC_027818

Anthony et al. 2015. Discovery of a novel hepatovirus (phopivirus of seals) related to human hepatitis A virus. MBio 6 (4):e01180-15.

Hepatovirus cemanavi

(formerly
Hepatovirus C)

HepV-C1

hepatovirus C1 (bat hepatovirus)
strain SMG18538Minmav2014

7570 nt

KT452742

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus devoli

(formerly
Hepatovirus D)

HepV-D1

hepatovirus D1 (rodent hepatovirus)
strain RMU10163Micarv2010

7656 nt

KT452637

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

NC_001489

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-D2

hepatovirus D2 (rodent hepatovirus)
strain KS111230Crimig2011

7632 nt

KT452644

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus erebubrufu

(formerly
Hepatovirus E)

HepV-E1

hepatovirus E1 (rodent hepatovirus)
strain CIV459Lopsik2004

7406 nt

KT452735

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus fejalco

(formerly
Hepatovirus F)

HepV-F1

hepatovirus F1 (rodent hepatovirus)
strain KEF121Sigmas2012

7563 nt

KT452685

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-F2

hepatovirus F2 (woodchuck hepatovirus) strain 2ID

7632 nt

KT229611

Yu et al. 2016. A novel hepatovirus identified in wild woodchuck Marmota himalayana. Sci. Rep. 6:22361.

Hepatovirus gafrisheta

(formerly
Hepatovirus G)

HepV-G1

hepatovirus G1 (bat hepatovirus)
strain BUO2BF86Colafr2010

7399 nt

KT452730

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-G2

hepatovirus G2 (bat hepatovirus)
strain FO1AF48Rhilan2010

7151 nt

KT452729

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus hedgi

(formerly
Hepatovirus H)

HepV-H1

hepatovirus H1 (hedgehog hepatovirus)
strain Igel8Erieur2014

6929 nt

KT452691

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

NC_028365

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-H2

hepatovirus H2 (bat hepatovirus)
strain M32Eidhel2010

7333 nt

KT452714

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-H3

hepatovirus H3 (tupaia hepatovirus)
strain TN1

7417 nt

KT877158

Ng et al., unpublished.

Hepatovirus ishrewi

(formerly
Hepatovirus I)

HepV-I1

hepatovirus I1 (shrew hepatovirus)
strain KS121232Sorara2012

7810 nt

KT452658

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

NC_028364

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.




top