Genus Hepatovirus

Genus Hepatovirus presently comprises 8 species:

Hepatovirus A, 1 type (hepatitis A virus, HAV)
Hepatovirus B, 1 type (phopivirus, PhV)
Hepatovirus C, 1 type (bat hepatovirus)
Hepatovirus D, 2 types (rodent hepatovirus)
Hepatovirus E, 1 type (rodent hepatovirus)
Hepatovirus F, 2 types (rodent hepatovirus)
Hepatovirus G, 2 types
Hepatovirus H, 3 types

Genome layout: VPg-5'UTRIRES-V[1A-1B-1C-1D/2A-2B-2Chel/3A- 3BVPg-3Cpro-3Dpol]3'UTR-poly(A)

This compilation is not comprehensive. There are more than 8100 GenBank entries (as of 22 October 2018) !

Species

Type

Strain

Length

Acc. No.

Reference

Hepatovirus A

HAV

hepatitis A virus (HAV)
strain HM-175

7478 nt

M14707

Cohen et al. 1987. Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J. Virol. 61 (1):50-59.

NC_001489

Cohen et al. 1987. Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J. Virol. 61 (1):50-59.

HAV

simian hepatitis A virus
strain AGM-27

7400 nt

D00924

Tsarev et al. 1991. Simian hepatitis A virus (HAV) strain AGM-27: comparison of genome structure and growth in cell culture with other HAV strains. J. Gen. Virol. 72 (PT 7):1677-1683.

Hepatovirus B

PhV

phopivirus
strain New England/USA/2011

7476 nt

KR703607

Anthony et al. 2015. Discovery of a novel hepatovirus (phopivirus of seals) related to human hepatitis A virus. MBio 6 (4):e01180-15.

NC_027818

Anthony et al. 2015. Discovery of a novel hepatovirus (phopivirus of seals) related to human hepatitis A virus. MBio 6 (4):e01180-15.

Hepatovirus C

HepV-C1

hepatovirus C1 (bat hepatovirus)
strain SMG18538Minmav2014

7570 nt

KT452742

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus D

HepV-D1

hepatovirus D1 (rodent hepatovirus)
strain RMU10163Micarv2010

7656 nt

KT452637

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

NC_001489

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-D2

hepatovirus D2 (rodent hepatovirus)
strain KS111230Crimig2011

7632 nt

KT452644

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus E

HepV-E1

hepatovirus E1 (rodent hepatovirus)
strain CIV459Lopsik2004

7406 nt

KT452735

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus F

HepV-F1

hepatovirus F1 (rodent hepatovirus)
strain KEF121Sigmas2012

7563 nt

KT452685

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-F2

hepatovirus F2 (woodchuck hepatovirus) strain 2ID

7632 nt

KT229611

Yu et al. 2016. A novel hepatovirus identified in wild woodchuck Marmota himalayana. Sci. Rep. 6:22361.

Hepatovirus G

HepV-G1

hepatovirus G1 (bat hepatovirus)
strain BUO2BF86Colafr2010

7399 nt

KT452730

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-G2

hepatovirus G2 (bat hepatovirus)
strain FO1AF48Rhilan2010

7151 nt

KT452729

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

Hepatovirus H

HepV-H1

hepatovirus H1 (hedgehog hepatovirus)
strain Igel8Erieur2014

6929 nt

KT452691

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

NC_028365

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-H2

hepatovirus H2 (bat hepatovirus)
strain M32Eidhel2010

7333 nt

KT452714

Drexler et al. 2015. Evolutionary origins of hepatitis A virus in small mammals. PNAS 112 (49):15190-15195.

HepV-H3

hepatovirus H3 (tupaia hepatovirus)
strain TN1

7417 nt

KT877158

Ng et al., unpublished.




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